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Is the Elixir Hydroxychloroquine that Trump Claimed Useful?

Recently, US President Trump has repeatedly recommended and praised Chloroquine, an existing drug used for the treatment of malaria, that the drug is effective for the treatment of new coronary pneumonia.

Trump Commends and Recommends Hydroxychloroquine

Trump called Chloroquine showing "very encouraging early effects" in the treatment of new coronary pneumonia and said that "Chloroquine has been approved by the US Food and Drug Administration (FDA) for the treatment of new crown virus".
But then FDA Commissioner Stephen denied the claim and said that chloroquine is undergoing clinical testing.

On March 21, Trump again strongly recommended the drug, saying "This is a gift from God, and we pray that it will be effective against coronavirus." According to the latest news, on March 29, the FDA has granted an emergency authorization to allow "chloroquine" and "hydroxychloroquine" to be used for coronavirus treatment.

Chloroquine a Special Drug for COVID-19 Treatment

Is "Chloroquine" a special drug for the treatment of new coronary pneumonia? In this regard, Zhong Nanshan, the leader of the high-level expert group of the National Health and Health Commission and an academician of the Chinese Academy of Engineering, gave an answer in an exclusive interview with He Jiaqi, a reporter of Shenzhen TV's 'Deep Vision News.'

What exactly are "chloroquine" and "hydroxychloroquine"?

According to an article published by C & EN under the American Chemical Society:

Chloroquine (chloroquine) is an immunomodulator used to treat malaria and some immune diseases. Hydroxychloroquine (hydroxychloroquine) is a chemically modified chloroquine derivative. 

Its mechanism of action is similar to that of chloroquine. It is considered to be less toxic and is more widely used. They are all "old drugs" for the treatment and prevention of malaria.

Chloroquine has been proven effective in clinical use

Zhong Nanshan said in an exclusive interview:
"Currently using chloroquine in China has proven its effectiveness. Then started using hydroxychloroquine abroad, because they are less chloroquine, so they added a hydroxyl group called hydroxychloroquine. Then hydroxychloroquine It seems that the preliminary research has some effects. "
Trump has repeatedly recommended and praised Chloroquine, an existing drug used for the treatment of malaria, that the drug is effective for the treatment of new coronary pneumonia, simulation

The reporter found out that before, Zhong Nanshan had made it clear on February 18 that chloroquine phosphate was helpful for the treatment of patients. 
On February 19, Zhong Nanshan mentioned chloroquine in an interview. 
On March 18, Zhong Nanshan pointed out that chloroquine was not harmful, and it was more effective for the conversion rate of coronary disease.

On February 19th, in the "New Coronavirus Infection Pneumonia Diagnosis and Treatment Program (Trial Version 6)" issued by China's National Health and Health Commission, chloroquine phosphate has been included as a trial drug for antiviral therapy.

Is "hydroxychloroquine + azithromycin" useful?

On March 21, Trump tweeted to continue to tout "hydroxychloroquine and azithromycin", saying that hydroxychloroquine combined with azithromycin may have a disruptive role in the history of drugs to suppress the new coronavirus. 
The tweet said: "I hope they can be put into use immediately. 
The people are struggling to die, move fast, and God bless you.

Hydroxychloroquine + azithromycin effects
Zhong Nanshan believes that the prescription of hydroxychloroquine + azithromycin, which is rumored to have extraordinary effects, needs more time to study.

"Hydroxychloroquine + azithromycin seems to be a theory at present. So far, only 20 cases have been done in France, the proportion is too small, especially the addition of azithromycin. 

Because we know the medicine of chloroquine and Azithromycin , Will cause some obstacles to heart conduction, we call it QT interval prolonged conduction block, so I think there must be sufficient evidence. "

Zhong Nanshan believes that hydroxychloroquine + azithromycin requires more time in theory and practice. It's not very suitable now, and it will be used without any result.

The reporter noted that in the 7th edition of China's new coronary pneumonia diagnosis and treatment plan, while giving a detailed medication plan for the use of chloroquine phosphate, it also gave a reminder of contraindications-CVD for patients with cardiovascular disease.

There is no special medicine for the time being, only effective medicine

Zhong Nanshan said: "In all the data of the 7th edition of the diagnosis and treatment plan in China, drugs are recommended only with preliminary results. It cannot be said that they can be recommended in theory. 

Because doing research work, scientific research and clinical are two different things. Scientific research can do Many studies, but recommended for the majority of clinical patients, must be very cautious. Considering its effectiveness, we must pay special attention to its safety. "

Therefore, Zhong Nanshan made it clear that there is currently no specific drug for the new coronavirus, only effective drugs.



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