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Patients with Residual Virus in Eyes, Sequelae of New Coronavirus

Patients have Residual COVID-19 Virus Residue in Eyes. 10 Types of Sequelae of New Coronavirus

South Korean survey shows that nearly 50% of patients have residual virus, residual in eyes, and 10 types of sequelae of new coronavirus.
According to Yonhap News Agency, a mid-term result of a trial released by the Korean Ministry of Disease Management on the 22nd showed that nearly half of the cases that were cured after infection with the new coronavirus and produced antibodies in the body remained virus in the body.

Production of neutralizing antibodies after infection with new coronavirus

The results of an analysis of 25 patients by the Korean Department of Disease Management showed that these cases produced neutralizing antibodies after infection with the new coronavirus, but 48% (12 of them) were positive in the sputum genetic test.

South Korean survey shows that nearly 50% of patients have residual virus, residual in eyes, and 10 types of sequelae of new coronavirus

At a press conference on the 22nd, the head of the South Korean Central Epidemic Prevention Headquarters, Zheng Yinjing, said that the epidemic prevention department speculated that the virus could not be completely eliminated after the neutralizing antibody was produced in the case. Also, the time that the virus remained in the body varied.

It is reported that the Korean epidemic prevention department conducted a virus multiplication test on 12 people who tested positive, and the first test result was negative. Zheng Yinjing said that further research is under way.

Coronavirus remains in the eyes of patients

Recently, a study showed that even if the new coronavirus in the nasal cavity of patients with new coronary pneumonia is cleared, the new coronavirus will remain in the eyes of the patients for a few days.

According to a report by Fox News on the 22nd, researchers at the National Institute of Infectious Diseases (INMI) in Lazzaro Spallanzani, Rome, Italy, published a research report in the Annals of Internal Medicine on April 17. 

According to the report, a 65-year-old woman was among the first patients diagnosed with new coronavirus in Italy. 
The medical staff detected a certain level of new coronavirus from her eyes long after the new coronavirus in her nasal cavity was cleared of Infectiousness.

Half of the patients have residual crown virus

South Korean survey shows that nearly 50% of patients have residual virus, residual in eyes, and 10 types of sequelae of new coronavirus

It is reported that the woman flew from Wuhan, China to Italy on January 23. 
Less than a week later, she began to develop typical symptoms of new coronary pneumonia, such as dry cough, sore throat, inflammation of the nasal mucosa and red eyes. 
She was taken to the hospital for hospitalization the next day. 
After testing, the woman's new coronavirus test was positive. 
A few days later, she developed fever, nausea and vomiting again.

Simulation for Nearly 50% of patients have residual virus, residual in eyes, and 10 types of sequelae of new corona virus.

When the medical staff examined her eye swab, she found that the new coronavirus was present in the woman’s eye, and the new coronavirus was still found in her eye 27 days after the woman was admitted to the hospital. For several days.

SARS-CoV-2 virus no in nasal swabs found in eye swabs

Researchers at the National Institute of Infectious Diseases at Lazzaro Spalanzani pointed out in the report that SARS-CoV-2 virus not detected in nasal swabs was found in eye swabs a few days later.
"We found that the eye fluids of patients with new coronary pneumonia may carry infectious viruses, so the eyes may become a potential source of infection." 

The researchers wrote, "These findings emphasize the importance of preventive measures such as avoiding touching the nose. Eyes and wash your hands often. "

The researchers emphasize that the eye may be both an entrance to the virus and a source of transmission. Therefore, the researchers warned ophthalmologists to be extra careful when conducting examinations.

"In addition, we found that the virus may appear in the eye in the early stage of the new coronavirus infection, which shows that we must implement relevant measures to prevent the spread of the new coronavirus as soon as possible." The researchers wrote.

A few people will have certain sequelae after the new coronavirus is cured

According to my research related data, the related sequelae currently reported are mainly the following categories:

1. Pulmonary fibrosis

Because the main pathogenesis of the new coronavirus is in the lungs, a large amount of inflammatory exudation of the lungs seriously damages lung function. 

So even after the cure, there will be different levels of residual lung function. 

When discharged from the hospital, there will be certain obstacles to lung function, such as pulmonary fibrosis.

2. Respiratory distress syndrome

Up to now, more than 2.4 million cases of new coronary pneumonia have been diagnosed worldwide.

Relative to death cases, the successful treatment still accounts for the vast majority, and it is also a survivor. 

However, some experts in the world predict that after successful treatment, they may later develop into acute respiratory distress syndrome (ARDS). This will cause sequelae that affect the rest of their lives.

Patients with new crowns in ICU have ARDS
An article in the Times published on March 15 reported that the British Critical Care Research Institute found that 17% of patients with new crowns who had entered the ICU would have ARDS.

George Washington University, Dean of the Milken School of Public Health, Lynn Goldman pointed out, "Some survivors will always have some problems, depending on the severity of ARDS, and some injuries will accompany life."

3. Liver damage

The researchers found that COVID-19-induced liver injury is closely related to the innate immune dysfunction caused by the virus.

Coronavirus can cause liver damage, and the manifestation of abnormal liver function in patients is obviously mild. The elderly with liver injury are more likely to be recruited.

South Korean survey shows that nearly 50% of patients have residual virus, residual in eyes, and 10 types of sequelae of new coronavirus

Hepatic insufficiency in patients with severe COVID-19 is accompanied by more activation of coagulation and hemolytic fiber pathways.

At the same time, patients with low platelet count, neutrophil count and neutrophil-to-lymphocyte ratio will increase, ferritin The level rises.

South Korean survey shows that nearly 50% of patients have residual virus, residual in eyes, and 10 types of sequelae of new coronavirus.

Secondary liver injury after a new crown

The top medical journal "The Lancet" published a study on 99 cases of new coronary pneumonia on January 30, Beijing time, and it has already paid attention to the liver damage of patients. 
The paper mentioned that patients with new coronary pneumonia with liver injury as the first manifestation is very rare, and secondary liver injury is more common. 

For patients with chronic liver disease and cirrhosis, the risk after COVID-19 is higher. Because compared with other severely ill patients, these patients have poor immune function, which may lead to acute respiratory distress syndrome (ARDS) which will lead to a worse disease outcome.

4. Impairment of renal function by nCOVID

On March 6, 2020, Chen Yongwen of the Third Military Medical University and Wu Yuzhang (the People's Liberation Army Central Warfare General Hospital as the first unit) jointly published a message on the pre-printed platform medRxiv titled 
"Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection” research paper, which analyzed 85 laboratory-confirmed COVID-19 patients.

These patients were hospitalized in a hospital in Wuhan from January 17 to March 3, 2020. 
Glomerular filtration rate (eGFR), plasma creatinine and urea concentrations, and other clinical parameters were collected.  

In addition, the study used hematoxylin and eosin (H & E) to analyze the kidney tissues of six other autopsy patients and passed the immunization Histochemical detection of in situ expression of viral nucleocapsid protein (NP) antigen.

SARS-CoV-2 virus can directly infect human renal tubules

The study found that SARS-CoV-2 virus can directly infect human renal tubules (immunohistochemistry shows that SARS-CoV-2 NP antigen accumulates in the renal tubules), resulting in acute renal tubular damage.

In addition, the improvement of eGFR will increase the survival rate of COVID-19 patients with ARF. SARS-CoV-2 virus directly infects human renal tubules and may also cause urine transmission.

On February 12, Chen Xiaowei and others from the Third Military Medical University published the latest clinical observation study in medRxiv and found that renal insufficiency is common among patients with new coronary pneumonia.

Therefore, it is strongly recommended that medical personnel should pay special attention to the kidney when monitoring patients with new coronary pneumonia Features. 

A series of related studies and clinical observations have found that the new coronavirus can not only infect the respiratory system, but also suffers from kidney damage and even functional failure.

These findings suggest that in addition to infecting the lungs, the new coronavirus may also infect other organs of the human body.

Some symptoms such as loss of appetite, diarrhea, abdominal pain, and abdominal discomfort are symptoms of gastrointestinal damage.

5. Heart amage from Coronavirus

According to a news agency in the new media special "Scientific American" Monthly, an article on April 6th said that although the focus of the new crown epidemic is on respiratory problems and ensuring that there are enough ventilators, frontline doctors are working hard to solve a new medical mystery.

In addition to lung damage, many patients with new crowns also have heart problems-death from cardiac arrest.

The article said that more and more cardiologists from China, Italy and Washington State and New York State are beginning to believe that the new coronavirus can infect the heart muscle. 

A preliminary study found that one in five patients had a damaged heart, and even in patients without signs of respiratory distress, it could cause heart failure and death.

New heart problem is caused by the crown virus

The article pointed out that whether the new heart problem is caused by the virus itself or the side effects of the body's reaction to it. This problem has become a major unknown for doctors who are competing to understand this new disease.

Robert Bono, a cardiology professor at Northwestern University's Feinberg School of Medicine, and many other cardiologists believe that infection with the new coronavirus may cause four or five forms of damage to the heart.

6. Gastrointestinal damage from Coronavirus

This new coronavirus mainly infects the respiratory system, which in turn leads to pneumonia. In addition to severely affecting lung function, a series of related studies and clinical observations have found that the new coronavirus also has multiple organ damage such as gastrointestinal tract and heart.

7. Hormone sequelae

Glucocorticoid drugs may be used during the treatment of new coronavirus pneumonia. A certain degree of centripetal obesity will appear after the patient is discharged from the hospital, the face appears to be floating, and the skin becomes thinner.

South Korean survey shows that nearly 50% of patients have residual virus, residual in eyes, and 10 types of sequelae of new coronavirus

Some have other complications, such as endocrine disorders and melanin deposition.

However, this kind of sequelae is not very obvious, it has a very limited impact on the body, and it can be recovered after a certain period of time, and then the symptoms will gradually disappear.

8. Weak constitution and loss of ability to work

France24, the official French television station, revealed in an interview with medical experts on April 2 that new coronary pneumonia may cause long-term damage to patients' lungs, heart, brain and other organs. 
For some patients, related complications are irreversible damage.
It may be lifelong.

George Washington University, Dean of the Milken School of Public Health, Lynn Goldman pointed out, "New Coronary Pneumonia is a disease that can be large or small. If you have proper medical conditions, you can survive, but some survivors will There have been some problems, depending on the severity of ARDS, some injuries will be accompanied by life. "

And Dr. Angel Jean Gajik, a medical expert at Mayo Hospital in Rochester, Minnesota, said, "A large number of survivors with ARDS are unable to work."

Some of them may be weak due to the multi-system damage caused by the new coronavirus, making it difficult for ordinary people to have the new ability to work, which makes them incapable of performing social work.

9. Psychological trauma

US media: Scientists warn that the new crown epidemic may cause unprecedented psychological trauma. 
Xinhua News Agency, Beijing, March 30, the new media specialty US media said that researchers warned that the new coronary pneumonia pandemic may cause unprecedented scale of lasting emotional trauma globally, perhaps forcing millions of people to work hard to deal with physical and mental fatigue psychological disorder.

According to a report by the US Consumer News and Business Channel website on March 27, experts in trauma psychology say that the New Coronary Pneumonia Crisis combines multiple sources of mental health stress. These have previously been studied in other disasters, but people have never seen them integrate in a global crisis.

Epidemic has no borders

New York State Institute of Psychiatry head of trauma and post-traumatic stress disorder Department of Columbia University Medical Center psychology professor Yuval Neria said: 
"The scale of this epidemic as a traumatic event is almost unimaginable." 

Because The anxiety caused by these events is at least geographically restricted. 
He said that the epidemic "has no borders".

Elana Newman, a trauma and disaster mental health researcher at the University of Tulsa in the United States, said, "This is a large-scale community disaster, but it is also a bit like terrorism, because of the fear component, the persistent fear." 

Newman said : "We recognize from large-scale disasters that it is more difficult for people who have suffered direct interpersonal or economic losses to cheer up."

Experts say that people who have fallen into economic difficulties or lost loved ones due to the epidemic crisis are also the most vulnerable to lasting psychological trauma. People with mental health problems such as addiction are also threatened.

10. Other possible symptoms

Other unpredictable sequelae can also occur.

For example, the United States is one of the regions with the highest incidence of epidemics, and more than 650,000 people have been affected so far.

One case had to be explained. Nick Cordero, a Broadway actor, was unfortunately infected with new crown pneumonia. 
At first, Nick Cordero developed symptoms, but he was negligent because of the negative test of the two new crowns.

On March 31, Nick Cordero was seriously ill after being diagnosed for the third time and was sent to the intensive care unit.

Unexpectedly, last Saturday night in the middle of the night, Nick Cordero's condition suddenly turned sharply, cardiac arrest also lost his pulse, and various organs also experienced serious adverse reactions.

After overnight rescue, Nick Cordero finally retrieved his life, but because the body organs are failing, emco, kidney dialyzer and blood drainage have been used to prevent the right leg from shrinking.

Nick Cordero still failed to keep his right leg and had completed an amputation operation.

Whether the above cases are complications or sequelae is not easy to distinguish. The only thing that can be said is that the new coronavirus has multiple damages to the human body, and various levels of sequelae will occur.

It should be emphasized that our country has achieved very good results in the prevention and treatment of new coronaviruses, and this is also due to the coordinated operations of Chinese and Western medicine.

Ayurveda, traditional Chinese medicine, acupuncture and its integrated treatment methods have an irreplaceable role in the prevention and treatment of the sequelae of the virus.

Theories such as adjusting qi and blood yin and yang, viscera function, syndrome differentiation and treatment, supporting and eliminating evil, etc. are very important for the prevention and treatment of sequelae of the new coronavirus.

It should also be emphasized that the theory of acupuncture and meridian in traditional Chinese medicine is indispensable for the treatment of sequelae based on syndrome differentiation and treatment.

What we have to do is: It is advisable to chase the remaining courageous courage and the new crown virus to prevent the aftermath.


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