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Does Biotin refer to Vitamin H?

 

Biotin generally refers to Vitamin H

Biotin, also known as vitamin H and coenzyme R, is a water-soluble vitamin and also belongs to the vitamin B family, B7. It is a necessary substance for the synthesis of vitamin C and an indispensable substance for the normal metabolism of fat and protein. It is a nutrient necessary to maintain the natural growth, development and normal function of the human body.


Can Biotin prevent hair loss and skin damage?

Biotin is one of the B vitamins, also known as vitamin H, vitamin B7, coenzyme R (Coenzyme R) and so on. 

In the 1930s, when studying the growth and respiration promoting factors of yeast growth factors and rhizobia, it was discovered from the liver as a factor that can prevent hair loss and skin damage in rats induced by feeding raw egg protein. 


Where can we find Biotin?

Biotin is a member of the water-soluble vitamin B group. It is abundant in liver, kidney, yeast, and milk, and is an important factor for organisms to fix carbon dioxide. 


Can eating a lot of raw protein hinder biotin absorption?

It is easy to combine with one of the proteins in chicken egg white. Eating a lot of raw protein can hinder the absorption of biotin and lead to biotin deficiency, such as hair loss, weight loss, dermatitis, etc. 

Biotin plays an important role in biochemical reaction pathways such as fat synthesis and gluconeogenesis.


How can Biotin help bald people?

Biotin is the savior of bald people. It not only prevents hair loss and light on the top of the head, but also prevents teenage gray hair that is common in modern people. 

It also plays an important role in maintaining skin health. As for the effect of stabilizing the nervous system, it has not been confirmed, but it is indeed helpful for depression and insomnia.

Biotin is a coenzyme of various carboxylases and acts as a CO2 carrier in the carboxylase reaction.

Chinese name vitamin H foreign name vitamin H alias biotin, coenzyme R category water-soluble vitamin food source strawberry


Table of Contents

 

1. Basic information

2. Performance and use

3. Features

4. Physiological functions

5. Main applications

    ▪ Health use

    ▪ Cosmetic use

    ▪ Research use

6. Symptoms of Deficiency

7. Toxicity

8. Food sources

9. Little knowledge

10. Knowledge development

 

 


Biotin (Basic Information )

Asian name: Biotin 

English name: Vitamin H

Alias: vitamin H; D-biotin; D-(+)-biotin; VH


Vitamin H

Biotin alias: D-Biotin; Biotin; Vitamin B7; Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid; Vitamin H (D-Biotin); D-Biotin pure; VH; 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid; 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d ]imidazol-4-yl]pentanoic acid; 5-[(3aR,4S,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid; 5-[(3aS, 4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate; 5-[(3aS,4S,6aS)-2-oxohexahydro-1H-thieno[3,4- d]imidazol-4-yl]pentanoate; 5-[(3aR,4S,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate;5-[(3aR,4S ,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate

CAS: 58-85-5

EINECS: 200-399-3

Molecular formula: C10H16N2O3S

Molecular weight: 244.3032

Melting point: 232-233C

Vitamin H


Specific optical rotation: 89 º (c=1, 0.1N NaOH)

Refractive index: 90.5 ° (C=2, 0.1mol/L NaOH)

Character and stability:

It is a colorless long needle-like crystal with a parallel ring combining urea and thiophene with a valeric acid side chain; very slightly soluble in water (22mg/100ml water, 25) and ethanol (80mg/100ml, 25) , more soluble in hot water and dilute lye, insoluble in other common organic solvents. In case of strong alkali or oxidant, it will decompose.

It can be stable for several days in medium-strength acid and neutral solutions, and is less stable in alkaline solutions. Fairly stable at ordinary temperatures, but high temperature and oxidizing agents can make it inactive.

In vivo process: Oral biotin is rapidly absorbed from the stomach and intestinal tract. 80% of biotin in the blood exists in free form and is distributed in various tissues of the body. Excreted in urine, only a small part is metabolized to biotin sulfur oxide and dinorbiotin.  


Performance and Usage 

1. Enhance the body's immune response and resistance. Biotin can enhance the body's immune response and infection resistance, stabilize the lysosomal membrane of normal tissues, maintain the body's humoral and cellular immunity and affect the secretion of a series of cytokines. Large doses can promote thymus hyperplasia, as combined with immune enhancers, can enhance immunity.  

2. Maintain normal growth and development. When biotin is deficient, reproductive function declines, bone growth is poor, and the growth and development of embryos and young children are hindered.

For the treatment of arteriosclerosis, stroke, abnormal lipid metabolism, hypertension, coronary heart disease and blood circulation disorders.

Used in cosmetics, it can improve the circulation speed of blood in the blood vessels of the skin. In the concentration range of 0.1%~1.0%, it is easy to mix with the oil in the formula. It can be used in skin care vanishing cream, sports liquid, foot pain cream, shaving liquid, and shampoo.


Who discovered Biotin (Vitamin H)?

In 1936, two German scientists, Kogl and Tonnis, isolated and extracted a crystalline substance from boiled duck egg yolk, which is necessary for the growth of yeast, and called it 'biotin'. 

Biotin is widely found in various organisms in nature and is an indispensable element for the maintenance of human and animal health, hence the name. 

Because of its wide distribution in food, almost every food contains a small amount of biotin, and the daily requirement of the human body is very small, so people generally do not lack this vitamin.  


Features of Biotin

Infographics showing Vitamin H molecular formula

Physiological effects: Biotin is combined with enzymes to participate in the fixation and carboxylation of carbon dioxide in the body, and is converted into oxaloacetate with important metabolic processes in the body such as carboxylation of pyruvate, carboxylation of acetyl-CoA into sugars such as malonyl-CoA and major biochemical reactions in fat metabolism. 

It is also a growth factor for certain microorganisms, and very small amounts (0.005 micrograms) are sufficient for the growth of the tested bacteria. For example, N. sp. requires very small amounts of biotin for growth. 

The human body needs about 100 to 300 micrograms per day. There is an avidin protein in raw egg whites that can combine with biotin, and the combined biotin cannot be absorbed by the digestive tract; resulting in a lack of biotin in animals, loss of appetite, glossitis, dandruff dermatitis and hair loss. However, no cases of human biotin deficiency have been seen, possibly due to biotin synthesis by gut bacteria in addition to food sources.


What is the Efficacy of Biotin?

Vitamin H is a key regulatory element in the synthesis of glycogen, the synthesis of fatty acids and the metabolism of certain amino acids, and can promote the synthesis of certain proteins by helping energy production. 

Biotin:

  • Assists cell growth
  • Manufactures fatty acids
  •  Metabolizes carbohydrates Fats and proteins, and helps in the utilization of B vitamins
  • Promotes the health of sweat glands, nerve tissue, bone marrow, and male gonads
  • Maintains the normal operation and growth of skin and hair, and relieves eczema, dermatitis symptoms
  • Prevents white hair and hair loss, help to treat baldness
  • Ease muscle pain
  • Indeed help with depression and insomnia
  • Participate in the metabolism of vitamin B12, folic acid, pantothenic acid
  • Promotes urea synthesis and excretion
  • Aids Immune Function



Physiological Function of Biotin

The human body needs about 100 to 300 micrograms per day. There is an avidin protein (egg protein, avidin) in raw egg white that can combine with biotin, and the combined biotin cannot be absorbed by the digestive tract resulting in a lack of biotin in animals, loss of appetite, glossitis, dermatitis, hair loss, etc. However, no cases of human biotin deficiency have been seen, possibly due to biotin synthesis by gut bacteria in addition to food sources. 

Biotin is a coenzyme of various enzymes in the human body which:

  • Participates in the metabolism of fatty acids and carbohydrates in the body
  • Promotes protein synthesis also participates in the metabolism of vitamin B12, folic acid, and pantothenic acid
  • Promotes urea synthesis and excretion
  • Helps the normal synthesis and metabolism of fat, glycogen and amino acids in the human body
  • Promote the normal operation and growth of sweat glands, nerve tissue, bone marrow, male gonads, skin and hair, and relieve symptoms of eczema and dermatitis
  • Prevent gray hair and hair loss, and help to treat baldness
  • Relieve muscle pain
  • Promote urea synthesis and excretion, purine synthesis and oleic acid biosynthesis.
  • Used for the treatment of arteriosclerosis, stroke, abnormal lipid metabolism, hypertension, coronary heart disease and blood circulation disorders
  • If biotin is used together with vitamin A, vitamin B2, vitamin B6, and niacin (vitamin B3), they complement each other and work better


What is the Supplementary cycle of BVitamin H?

Vitamin H only stays in the human body for 3 to 6 hours, so it must be supplemented every day.  


Main Application of Vitamin H (Biotin)

Biotin, better known as vitamin H, enables the body to convert food into its own energy. Biotin is beneficial for cell health and regeneration. 

Diabetics can improve blood sugar regulation with biotin. 

Biotin is also required for hair and nail health.  


What is the Health use of Biotin?

diabetes. Supplementing with biotin, biotin helps improve blood sugar regulation by improving insulin and blood sugar use.

Hair and nails: Supplementing with biotin can repair weak, cracked toenails and fingernails and improve hair health. Biotin can also repair those premature graying of hair caused by low biotin levels.

Genetic problems: some babies don't use biotin well and need biotin supplements.

Skin problems; some skin conditions, such as cradle cap, can be improved with biotin supplementation.

Muscular dystrophy: biotin may be used as part of a course of treatment for certain muscle-related disorders.

Nutritional health: Biotin helps people who lose weight carry out a more efficient metabolism.

Infectious diseases: Biotin can be used to treat Candida (a type of yeast infection) in the intestine.

According to research, the compatibility of folic acid and biotin can effectively prevent teratogenicity. 

At the beginning of 2008, the Japanese Ministry of Health and Welfare officially announced that both biotin and folic acid will be taken as mandatory nutrients for pregnant women in Japan. 

It is certain that the decision of the Ministry of Health and Welfare will greatly promote the sales of biotin in Japan, and at the same time, it will also further promote the global consumption of biotin.

American researchers also found that biotin can promote the decomposition of fat and carbohydrates, so that they can be converted into energy required for human activities.

If the amount of biotin in the body is insufficient, fat will accumulate in the body and cause obesity. This new discovery has laid a solid foundation for the application of biotin in weight loss and slimming health care products, and has opened up a broader market for biotin.  


How can we make cosmetic use of Biotin?

At the same time, Japanese scholars also reported that biotin has an excellent cosmetic effect, which can keep the skin white and the nails smooth. This discovery also opens up a new pharmaceutical use for biotin products. 

The beauty and cosmetics industry is one of the major international industries. The total sales of beauty cosmetics in the international market is much higher than the sales of pharmaceuticals. This is as there is growth in vegetarian or organic sales rather than chemical.

Vitamin H as a nutritional supplement. According to China GB2760-90, it can be used in the food industry as a processing aid. 

It has physiological functions such as preventing skin diseases and promoting lipid metabolism. 

Eating large amounts of raw protein can lead to biotin deficiency.  

As a medicine, it is used for the treatment of arteriosclerosis, stroke, abnormal lipid metabolism, hypertension, coronary heart disease and blood circulation disorders.

Used in cosmetics, vitamin H can improve the speed of blood circulation in the skin blood vessels. In the concentration range of 0.1%-1.0%, it is easy to mix the oil phase in the formula. It can be used in skin care vanishing cream, sports liquid, foot pain cream, shaving liquid and shampoo.


How can we make Research use of Biotin?

Biotin can be used as a label for nucleic acid probes, which can bind to C at the 5' position of UTP or dUTP of nucleic acid molecules, and can be detected by binding to avidin. In the process of detection, biotin is only used for immobilization, not for signal detection.  


Symptoms of Biotin (Vitamin H) Deficiency 

1. Lack of biotin increases dandruff, easy hair loss, and white hair in teenagers;

2. Lack of biotin can cause dull complexion, bluish complexion, and dermatitis;

3. Lack of biotin can easily lead to neurological symptoms such as depression, insomnia, and easy dozing;

4. Lack of biotin can make you tired, lethargic, and muscle pain.


What are the signs of biotin deficiency:?

The signs of Biotin deficiency include:

  • Dermatitis
  • Eczema
  • Atrophic glossitis
  • Hyperesthesia
  • Muscle pain
  • Lethargy
  • Anorexia and mild anemia
  • Hair loss

 

Toxicity of Biotin

The toxicity of biotin appears to be low, and no abnormal protein metabolism or genetic errors and other metabolic abnormalities have been found in seborrheic dermatitis treated with high doses of biotin. 

Animal experiments also show that biotin is less toxic.  


What is Food Source of Biotin?

Biotin is contained in milk, beef liver, egg yolk, animal kidney, strawberry, grapefruit, grape and other fruits, lean meat, brown rice, beer, and wheat. Vitamin H is usually included in preparations of B complex and multivitamins.

Vitamin H Strawberry Source


Foods rich in this vitamin: mustard double crisp, crab meat broccoli, mustard spinach, fish fragrant kidney flower, braised eel, vegetarian fried three silk, egg yolk pumpkin, mango orange apple juice, carrot stewed lamb, mussels Congee, Stewed Beef with Carrots, Yinqi Mingmu Soup, Chicken Liver and Carrot Porridge, Beef and Vegetables

Vegetable bisque, mango grapefruit juice, mango orange apple juice, papaya ginger juice, aloe vera lemon juice, sweet orange lemon juice, apricot kiwi juice.  


Little Knowledge  on Vitamin H

Recommended daily intake: Adults are recommended to take 25 to 300 μg per day. Biotin and vitamins (vitamin foods) A, B2, B6, and niacin are more effective when used together.

Supplementary cycle: Vitamin B7 only stays in the human body for 3 to 6 hours, so it must be supplemented every day.

People who need: People who eat raw eggs and drink alcohol need to supplement biotin; people who take antibiotics or sulfa drugs should take at least 25 μg per day.

Men with thin hair (male food) consume biotin to prevent hair loss. During this period, biotin will be lost significantly, and it should be supplemented reasonably under the guidance of a physician.

Biotin (Vitamin H) Deficiency: Biotin (Vitamin H) Biotin (Vitamin H) deficiency is mainly manifested by skin symptoms, including thinning hair, loss of luster, dry skin, scaly dermatitis, red rash, In severe cases, the rash can extend around the eyes, nose and mouth. 

In addition, accompanied by loss of appetite, nausea, vomiting, tongue papilla atrophy, mucous membrane graying, numbness, mental depression, fatigue, myalgia, hypercholesterolemia and abnormal EEG. 

Most of these symptoms occur after 10 weeks of biotin (vitamin H) deficiency. Seborrheic dermatitis may occur in infants under 6 months.

Biotin (vitamin H) overdose: The toxicity of biotin (vitamin H) is very low, and there have been no reports of biotin (vitamin H) toxicity.  


Vitamin H Knowledge Development 

Folic Acid function: to produce red blood cells and white blood cells, enhance immunity.

Deficiencies: red and swollen tongue, anemia, indigestion, fatigue, graying of hair, memory loss. 

Main food sources of Vitamin H (Biotin): vegetables, meat, yeast, etc.

Vitamin C (ascorbic acid) function: fights free radicals, helps prevent cancer; lowers cholesterol, strengthens body immunity, and prevents scurvy. 

Deficiency: bleeding gums, tooth loss; weak capillaries, slow wound healing, subcutaneous bleeding, etc. 

Main fruit sources: fruits (especially oranges), green vegetables, tomatoes, potatoes, etc.


Vitamin D function: assists calcium ion transport, helps children's teeth and bone development; supplements calcium for adult bones to prevent osteoporosis. 

Deficiency: rickets in children, loss of appetite, diarrhea, etc. 

Main non-veg food sources: cod liver oil, dairy products, eggs.

Vitamin E (tocopherol) function: antioxidant, help prevent cancer; fertility related.

 Deficiency: red blood cell damage, nerve damage, nutritional muscle atrophy, infertility, irregular menstruation, uterine dysfunction, etc. 

Main food sources: Vegetable oils, dark green vegetables, milk, eggs, liver, wheat and nuts.



 

Author's Bio



Name: Ian Skyler

Education: MBBS, MD

Occupation: Medical Doctor 

SpecializationCommunity Medicine, General Surgery, Natural Treatment

Experience: 18 Years as a Medical Practitioner

 


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