What are the treatments for Malignant Histiocytosis?
Disease analysis: There is no certain effective treatment for
malignant histiocytosis, and long-term treatment is required. Chemotherapy is
the main treatment method at present, but except for a few cases, most of them
have poor response or only short-term remission. In addition, allogeneic
Hematopoietic stem cell transplantation also has a certain effect.
The following can be treatments of Malignant Histiocytosis:
1. Drug treatment
1. Antibiotics: When symptoms such as infection and fever
occur, antibiotics such as chloramphenicol, erythromycin, and spiramycin can be
used to relieve symptoms.
2. Traditional Chinese medicine: There is no systematic
research and reliable plan for the treatment of malignant histiocytosis by
traditional Chinese medicine, which is limited to case reports. Combined
treatment of traditional Chinese medicine for yin and other functions.
2. Surgical treatment
Malignant histiocytosis has no surgical treatment, and is
mainly treated by chemotherapy and allogeneic hematopoietic stem cell
transplantation.
3. Chemotherapy
Chemotherapy is the main treatment method at present, but except for a few cases, most of them respond poorly or only cause short-term remission.
Studies have shown that the use of a combination regimen of several chemotherapy drugs including cyclophosphamide, doxorubicin, vincristine, prednisone, bleomycin, methotrexate, and procarbazine has a certain clinical effect. But there is also a lot of data that long-term use of alkylating agents can lead to the risk of acute myeloid leukemia.
The effects of other
chemotherapeutics alone are very poor, and there is currently no report on
pediatric chemotherapy experience. Commonly used combined chemotherapy regimens
include COP and COPP.
1. COP regimen: cyclophosphamide, vincristine, prednisone.
2. COPP program: cyclophosphamide, vincristine, procarbazine,
prednisone.
4. Other treatments
If conditions permit, the use of allogeneic hematopoietic
stem cell transplantation in the treatment of malignant histiocytosis also has
a certain effect. After finding a suitable stem cell provider, through
super-dose radiotherapy and chemotherapy, the malignant tissue cells in the
body are removed, and then allogeneic hematopoietic stem cells are returned to
rebuild the patient's hematopoietic function and immune function.
Author's Bio
Education: MBBS, MD
Occupation: Medical Doctor
Specialization: Community Medicine, General Surgery, Natural Treatment
Experience: 18 Years as a Medical Practitioner
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