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Treatments of Malignant Histiocytosis


What are the treatments for Malignant Histiocytosis?

Disease analysis: There is no certain effective treatment for malignant histiocytosis, and long-term treatment is required. Chemotherapy is the main treatment method at present, but except for a few cases, most of them have poor response or only short-term remission. In addition, allogeneic Hematopoietic stem cell transplantation also has a certain effect.

Treatments Malignant Histiocytosis Infographics

The following can be treatments of Malignant Histiocytosis:

1. Drug treatment

1. Antibiotics: When symptoms such as infection and fever occur, antibiotics such as chloramphenicol, erythromycin, and spiramycin can be used to relieve symptoms.


2. Traditional Chinese medicine: There is no systematic research and reliable plan for the treatment of malignant histiocytosis by traditional Chinese medicine, which is limited to case reports. Combined treatment of traditional Chinese medicine for yin and other functions.


2. Surgical treatment

Malignant histiocytosis has no surgical treatment, and is mainly treated by chemotherapy and allogeneic hematopoietic stem cell transplantation.


3. Chemotherapy

Chemotherapy is the main treatment method at present, but except for a few cases, most of them respond poorly or only cause short-term remission. 

Studies have shown that the use of a combination regimen of several chemotherapy drugs including cyclophosphamide, doxorubicin, vincristine, prednisone, bleomycin, methotrexate, and procarbazine has a certain clinical effect. But there is also a lot of data that long-term use of alkylating agents can lead to the risk of acute myeloid leukemia. 

The effects of other chemotherapeutics alone are very poor, and there is currently no report on pediatric chemotherapy experience. Commonly used combined chemotherapy regimens include COP and COPP.


1. COP regimen: cyclophosphamide, vincristine, prednisone.


2. COPP program: cyclophosphamide, vincristine, procarbazine, prednisone.


4. Other treatments

If conditions permit, the use of allogeneic hematopoietic stem cell transplantation in the treatment of malignant histiocytosis also has a certain effect. After finding a suitable stem cell provider, through super-dose radiotherapy and chemotherapy, the malignant tissue cells in the body are removed, and then allogeneic hematopoietic stem cells are returned to rebuild the patient's hematopoietic function and immune function.

Author's Bio

Name: Ian Skyler

Education: MBBS, MD

Occupation: Medical Doctor 

SpecializationCommunity Medicine, General Surgery, Natural Treatment

Experience: 18 Years as a Medical Practitioner


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